The Griffins and the other residents of Quahog are invited to the mansion of James Woods, who declares he wanted to make up for his wrongdoings. But the evening winds up with a series of mysterious murders, and guests are turning up dead and the remaining people tries to figure out who the murderer is.

Brian forms a new friendship with Rush Limbaugh, when the latter saves him from a violent street gang. Brian then became an obsessed follower and declares that he is now a Conservative Republican, going so far as following Limbaugh in Washington.

Peter finds out that his father in law is having an affair. When he accidentally reveals the affair, Lois’ mom demands a divorce and Peter now finds himself in charge of his father in law’s new found bachelorhood.

Brian and Stewie embark on an adventure to the North Pole, on a mission to kill Santa. But when they got there, they discover that Santa is sick because of his unreasonably full workload on Christmas day. They decided to help Santa deliver gifts, and were overwhelmed by the work, so they now ask everyone to wish for just one gift every Christmas day.

Chris and Meg think that it’s easier living the lives of their parents, so in order to give them a lesson, Lois and Peter suggest that they trade roles.